研究論文リスト Publication list

2000年~2009年
83. Kuroishi A, Saito A, Shingai Y, Shioda T, Nomaguchi M, Adachi A, Akari A, Nakayama EE: Modification of a loop sequence between alpha-helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV-1) derivative that has simian immunodeficiency virus (SIVmac239) vif and CA alpha-helices 4 and 5 loop improves replication in cynomolgus monkey cells. Retrovirology 6, 70, 2009.

82. Hassan R, Suzu S, Hiyoshi M, Takahashi-Makise N, Ueno T, Agatsuma T, Akari H, Komano J, Takebe Y, Motoyoshi K, Okada S: Dys-regulated activation of a Src tyrosine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms. Journal of Cellular Physiology 221, 458-468, 2009. (Epub July 7, 2009)

81. Iwasaki Y, Akari H, Murakami T, Kumakura S, Dewan MZ, Yanaka M, Yamamoto N: Efficient inhibition of SDF-1α-mediated chemotaxis and HIV-1 infection by novel CXCR4 antagonists. Cancer Science 100, 778-781, 2009. (Epub Feb 24, 2009)

80. Akari H, Iwasaki Y, Yoshida T, Iijima S: Non-human primate surrogate model of hepatitis C virus infection. Microbiology and Immunology 53, 53-57, 2009.

79. Izumi T, Takaori-Kondo A, Shirakawa K, Higashitsuji H, Itoh K, Io K, Matsui M, Iwai K, Kondoh H, Sato T, Tomonaga M, Ikeda S, Akari H, Koyanagi Y, Fujita J, Uchiyama T: Mdm2 is a novel E3 ligase for HIV-1 Vif. Retrovirology, 6, 1, 2009.

78. Hohjoh H, Akari H, Fujiwara Y, Hirai H, Wada K: Molecular cloning and characterization of the common marmoset huntingtin gene. Gene 432, 60-66, 2009. (Epub Nov 24, 2008)


77. Nakajima T, Ohtani H, Satta Y, Uno Y, Akari H, Ishida T, Kimura A: Natural selection in the TLR-related genes in the course of primate evolution. Immunogenetics 60, 727-735, 2008. (Epub Sep 23, 2008)

76. Kawada M, Tsukamoto T, Iwamoto N, Kurihara K, Takeda A, Moriya C, Takeuchi H, Akari H, Matano T: Gag-specific cytotoxic T lymphocyte-based viral containment in a macaque AIDS model. Journal of Virology 82, 10199-10206, 2008.

75. Sato H, Leo N, Katakai Y, Takano J, Akari H, Nakamura S, Une Y: Prevalence and molecular phylogeneic characterization of Trypanosoma (Megatrypanum) minasense in the peripheral blood of small neotropical primates (Saimiri sciureus and Saguinus midas) after a quarantine period.Journal of Parasitology 94, 1128-1138, 2008.

74. Hiyoshi M, Suzu S, Yoshidomi Y, Hassan R, Harada H, Sakashita N, Akari H, Motoyoshi K, Okada S: Interaction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor. Blood 111, 243-250, 2008.

73. Yokota T, Iijima S, Kubodera T, IshiiK, Katakai Y, Ageyama N, Chen Y, LeeY-J, Unno N, Nishina K, Iwasaki Y, Maki N, Mizusawa H, Akari H: Efficient regulation of viral replication by systemicallyadministered siRNA with cationic liposome in a non-human primate surrogate model for hepatitis C. Biochemical and Biophysical Research Communications 361, 294-300, 2007.

72. Hara M , Kikuchi T, Sata T, Nakajima N, Ami Y, Sato Y, Tanaka K, Narita T, Ono F, Akari H, Terao K, Mukai R: Detection of SRV/D shedding in body fluids of cynomolgus macaques and comparison of partial gp70 sequences in SRV/D-T isolates. Virus Genes 35, 281-288, 2007.

71. Ishii K, Iijima S, KimuraN, LeeY-J, Ageyama N, YagiS, Yamaguchi K, Maki N, Yoshizaki S, Machida S, Suzuki T, Iwata N, Sata T, Terao K, Miyamura T, Akari H: GBV-B as a pleiotropic virus: Distribution of GBV-B in extrahepatic tissues in vivo. Microbes and Infection 9, 515-521, 2007.

70. Shirakawa K, Takaori-Kondo A, Kobayashi M, Tomonaga M, Izumi T, Fukunaga K, Sasada A, Abudu A, Miyauchi Y, Akari H, Iwai K, Uchiyama T: Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex. Virology344, 263-266, 2006.

69. Fujita M, Akari H, Sakurai A, Yoshida A, Chiba T, Tanaka K, Strebel K, Adachi A: Expression of the HIV-1 accessory protein Vif is controlled uniquely to be low and optimal by proteasome-degradation. Microbes and Infection 6, 791-798, 2004.


68. Uda A, Tanabayashi K, Yamada YK, Akari H, Lee YJ, Mukai R, Terao K, Yamada A: Detection of Fourteen Alleles Derived from MHC Class I A Locus in CynomolgusMonkeys. Immunogenetics 56, 155-163, 2004.


67. Akari H, Fujita M, Kao S, Khan MA, Shehu-Xhilaga M, Adachi A, Strebel K: High level expression of Human immunodeficiency virus type 1 Vif inhibits viral infectivity by modulating proteolytic processing of Gag precursor at the p2/NC processing site. Journal of Biological Chemistry 279, 12355-12362, 2004.

66. Nguyen KL, Llano M, Akari H, Miyagi M, Poeschla EM, Strebel K, Bour S: Codon optimization of the HIV-1 vpu and vif genes stabilizes their messenger RNA and allows for highly efficient Rev-independent expression. Virology, 319, 163-175, 2004.

65. Lee WW, Nam KH, Terao K, Akari H, Yoshikawa Y: Age-related increase of peripheral CD4+CD8+ double positive (DP) T lymphocytes in cynomolgus monkeys: Longitudinal study in relation to thymic involution.Immunology 109, 217-225, 2003.

64. Ueno F, Shiota H, Miyaura M, Yoshida A, Sakurai A, Tatsuki J, Koyama AH,Akari H, Adachi A, Fujita M: Vpx and Vpr proteins of human immunodeficiency virus type 2 up-regulate the viral infectivity by a distinct mechanism in lymphocytic cells. Microbes and Infection, 5, 387-395, 2003.

63. Bour SP, Akari H, Miyagi E, Strebel K: Naturally-occurring amino acid substitutions in the HIV-2 ROD envelope glycoprotein regulate its ability to augment viral particle release. Virology 309, 85-98, 2003.

62. Fujita M, Yoshida A, Sakurai A, Tatsuki J, Ueno F, Akari H, Adachi A: Susceptibility of HVS-immortalized lymphocytic HSC-F cells to various strains and mutants of HIV/SIV. International Journal of Molecular Medicine 11, 641-644, 2003.

61. Sugimoto C, Tadakuma K, Otani I, Moritoyo T, Akari H, Ono F, Yoshikawa Y, Sata T, Izumo S, Mori K: Nef gene is required for robust productive infection of simian immunodeficiency virus in T-cell-rich paracortex in lymph nodes. Journal of Virology 77, 4169-4180, 2003.

60. Kao S, Akari H, Khan MA, Dettenhofer M, Yu X-F, Strebel K: Human immunodeficiency virus type 1 Vif is efficiently packaged into virions during productive but not chronic infection. Journal of Virology 77. 1131-1140, 2003.

59. Khan MA, Akari H, Kao S, Aberham C, Davis D, Buckler-White A, Strebel K: Intravirion processing of the human immunodeficiency virus type 1 Vif protein by the viral protease and its possible correlation with Vif function. Journal of Virology 76, 9112-9123, 2002.

58. Tomiyama H, Akari H, Adachi A, Takiguchi M: Different effects of Nef-mediated HLA class I down-regulation on HIV-1-specific CD8+ T cell cytolytic activity and cytokine production. Journal of Virology 76, 7535-7543, 2002

57. Akari H, Bour S, Kao S, Adachi A, Strebel K: The HIV-1 accessory protein Vpu induces apoptosis by suppressing the NF-kB dependent expression of anti-apoptotic factors. Journal of Experimental Medicine 194, 1299-1311, 2001

56. Fujita M, Yoshida A, Miyaura M, Sakurai A, Akari H, Koyama AH, Adachi A: Cyclophilin A-independent replication of a human immunodeficiency virus type 1 isolate carrying a small portion of simian immunodeficiency virus SIVmac gag capsid region. Journal of Virology 75, 10527-10531, 2001.

55. Khan MA, Aberham C, Kao S, Akari H, Gorelick R, Bour S, Strebel K: Human immunodeficiency virus type 1 Vif protein is packaged into nucleoprotein complex through an interaction with viral genomic RNA. Journal of Virology 75, 7252-7265, 2001.

54. Bour S, Perrin C, Akari H, Strebel K: The human immunodeficiency virus type 1 Vpu protein inhibits NF-kB activation by interfering with bTrCP-mediated degradation of IkB. Journal of Biological Chemistry, 19, 15920-15928, 2001.

53. Akari H, Yoshida A, Fukumori T, Adachi A: Host cell-dependent replication of HIV-1 mutants with deletions in gp41 cytoplasmic tail region is independent of the function of Vif. Microbes and Infection 2, 1019-1023, 2000.

52. Fukumori T, Akari H, Yoshida A, Fujita M, Koyama AH, Kagawa S, Adachi A: Regulation of cell cycle and apoptosis by human immunodeficiency virus type 1 Vpr. Microbes and Infection 2, 1011-1017, 2000.

51. Nam KH, Akari H, Terao K, Shibata H, Kawamura S, Yoshikawa Y: Peripheral blood extrathymic CD4+ CD8+ T cells with high cytotoxic activity are the same lineage with CD4+ CD8- T cells in cynomolgus monkeys. International Immunology, 12, 1095-1103, 2000.

50. Yoshida A, Miyaura M, Sakurai A, Fukumori T, Fujita M, Akari H, Adachi A: MHC-I expression in HTLV-1-positive and -negative cells. International Journal of Molecular Medicine 6, 83-86, 2000.

49. Akari H, Fukumori T, Adachi A: Cell-dependent requirement of human immunodeficiency virus type 1 gp41 cytoplasmic tail for Env incorporation into virions. Journal of Virology, 74, 4891-4893, 2000.

48. Akari H, Arold S, Fukumori T, Okazaki T, Strebel K, Adachi A: Nef-Induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation. Journal of Virology, 74, 2907-2912, 2000.