研究論文リスト Publication list

1990年~1999年

47. Otani I, Mori K, Sata T, Terao K, Doi K, Akari H, Yoshikawa Y: Accumulation of MAC387+ macrophages in paracortical area of lymph nodes in rhesus monkeys (Macaca mulatta) acutely infected with SIVmac239. Microbes and Infection, 1, 977-985, 1999.

46. Fujii Y, Akari H, Machida M, Kojima E, Murakami K, Yoshikawa Y: Effective delivery of a lipophilic 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) into rat lymphoid tissues. Experimental Animals, 48, 241-246, 1999.

45. Akari H, Uchiyama T, Fukumori T, Iida S, Koyama AH, Adachi A: Pseudotyping human immunodeficiency virus type 1 by vesicular stomatitis virus G protein does not reduce the cell-dependent requirement of Vif for optimal infectivity: functional difference between Vif and Nef. Journal of General Virology, 80, 2945-2950, 1999.

44. Akari H, Fukumori T, Iida S, Adachi A: Induction of apoptosis in Herpesvirus saimiri-immortalized T lymphocytes by blocking interaction of CD28 with CD80/CD86. Biochemical and Biophysical Research Communications 263:352-356, 1999.

43. Sakai K, Iida S, Fukumori T, Akari H, Adachi A: Mutational analysis of human immunodeficiency virus type 1 vif gene. Virus genes 18, 179-81, 1999.

42. Iida S, Yamamoto Y, Fukumori T, Akari H, Adachi A: Compatibility of Vpu-like activity in the four groups of primate immunodeficiency viruses. Virus genes, 18, 183-187, 1999.

41. Akari H, Nam KH, Mori K, Shibata H, Otani I, Adachi A, Terao K, and Yoshikawa Y: Effects of SIVmac infection on peripheral blood CD4+CD8+ T lymphocytes in cynomolgus macaques. Clinical Immunology 91, 321-329, 1999.

40. Fukumori T, Kagawa S, Iida S, Oshima Y, Akari H, Koyama AH, Adachi A: Rev-dependent expression of three species of HIV-1 mRNAs. International Journal of Molecular Medicine 3, 297-302, 1999.

39. Adachi A, Iida S, Fukumori T, Tamaki M, Inubushi R, Shimano R, Oshima Y, Akari H, Koyama AH: Exchangeability of accessory Vif and Vpu proteins between various HIV/SIVs. International Journal of Molecular Medicine 3, 193-197, 1999.

38. Koyama AH, Akari H, Adachi A, Goshima S, Nishiyama Y: Induction of apoptosis in HEp-2 cells by the infection with herpesvirus simplex virus type 2. Archives of Virology 143, 2435-2441, 1998.

37. Shimano R, Inubushi R, Tamaki M, Akari H, Koyama AH, Adachi A: The non-env tropism of HIV/SIV. International Journal of Molecular Medicine 2, 541-544, 1998.

36. Nam KH, Akari H, Terao K, Itagaki S, Yoshikawa Y: Age-related alterations of major lymphocyte subsets in cynomolgus monkeys. Experimental Animals 47, 159-166, 1998.

35. Tokunaga K, Kojima A, Kurata T, Ikuta K, Akari H, Kawamura M, Inubushi R, Shimano R, Adachi A: Enhancement of human immunodeficiency virus type 1 infectivity by Nef is producer cell-dependent. Journal of General Virology, 79, 2447-2453, 1998.

34. Shimano R, Inubushi R, Amano K, Ogasawara T, Akari H, Kawamura M, Adachi A: Complete inhibition of SIVmac replication by its capsid mutants. Virus Genes 17, 43-48, 1998.

33. Koyama AH, Irie H, Fukumori T, Hata S, Iida S, Akari H, Adachi A: Role of virus-induced apoptosis in a self-defense mechanism against virus infection. The Journal of Medical Investigation 45, 37-45, 1998.

32. Tokunaga K, Kojima A, Kurata T, Ikuta K, Inubushi R, Shimano R, Kawamura M, Akari H, Koyama AH, Adachi A: Producer cell-dependent requirement of the Nef protein for efficient entry of HIV-1 into cells. Biochemical and Biophysical Research Communications 250, 565-568, 1998.

31. Inubushi R, Shimano R, Koyama AH, Akari H, Adachi A: Functional roles of HIV accessory proteins for viral replication. International Journal of Molecular Medicine 2, 429-433, 1998.

30. Otani I, Akari H, Nam KH, Mori K, Suzuki E, Shibata H, Doi K, Terao K, Yoshikawa Y: Phenotypic changes in peripheral blood monocytes of cynomolgus monkeys acutely infected with simian immunodeficiency virus. AIDS Research and Human Retroviruses, 14, 1181-1186, 1998.

29. Kawamura M, Shimano R, Inubushi R, Akari H, Adachi A: Early function of HIV-1 Gag proteins is cell-dependent. Biochemical and Biophysical Research Communications 248, 899-903, 1998.

28. Fukumori T, Akari H, iida S, Hata S, Kagawa S, Aida Y, Koyama AH, Adachi A: The HIV-1 Vpr displays strong anti-apoptotic activity. FEBS Letters 432, 17-20, 1998.

27. Nam KH, Akari H, Terao K, Ohto H, Itagaki S, and Yoshikawa Y: Age-dependent remodeling of peripheral blood CD4+ CD8+ double-positive T lymphocytes in cynomolgus monkeys. Developmental and Comparative Immunology, 22, 239-248, 1998.

26. Kawamura M, Shimano R, Ogasawara T, Inubushi R, Amano K, Akari H and Adachi A: Mapping the genetic determinants of human immunodeficiency virus type 2 for cell tropism and replication efficiency. Archives of Virology, 143, 513-521, 1998.

25. Akari H, Mori K, Otani I, Terao K, Ono F, Adachi A and Yoshikawa Y: Induction of MHC-IIDR expression on circulating CD8+ lymphocytes in macaques infected with SIVmac239 nef-open but not with its nef-deletion mutant. AIDS Research and Human Retroviruses, 14, 619-625, 1998.

24.Akari H, Yagita H, Nishida T, Nakamaru K, Terao K, Yoshikawa Y, Adachi A: Selective induction of integrin expression on lymphoid tissue lymphocytes undergoing apoptosis. Biochemical and Biophysical Research Communications 244, 578-582, 1998.

23. Akari H, Yamamoto Y, Hiwada H, Saito Y, Takayanagi N, Koyama AH, Adachi A: Suppression of HIV-1 replication in peripheral blood mononuclear cells by fasudil. The Journal of Medical Investigation, 44, 211-214, 1998.

22. Fujii Y, Mukai R, Akari H, Machida M, Mori K, Takasaka M, Kojima E, Murakami K and Yoshikawa Y: Anti-viral effects of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) in rhesus monkeys acutely infected with simian immunodeficiency virus. Antiviral Chemistry and Chemotherapy, 9, 85-92, 1998.

21. Akari H, Ono F, Sakakibara I, Takahashi H, Murayama Y, Hiyaoka A, Terao K, Otani I, Mukai R, Adachi A and Yoshikawa Y: Simian T-cell leukemia virus type 1-induced malignant adult T cell leukemia-like disease in a naturally infected African green monkey: implication of CD8+ T cell leukemia. AIDS Research and Human Retroviruses 14, 367-371, 1998.

20. Akari H, Terao K, Nam KH, Adachi A and Yoshikawa Y: Comparative analysis of human and macaque monkey CD4: differences in formaldehyde lability and conformation. Experimental Animals 47, 23-27, 1998.

19. Kawamura M, Shimano R, Inubushi R, Amano K, Ogasawara T, Akari H and Adachi A: Functional domain mapping of HIV-1 Gag proteins. Biochemical and Biophysical Research Communications 241, 317-320, 1997.

18. Fujii Y, Mukai R, Mori K, Akari H, Otani I, Kojima E, Takasaka M, Machida M, Murakami K and Yoshikawa Y: Efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) on rhesus macaque monkeys chronically infected with simian immunodeficiency virus. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 16, 313-317, 1997.

17. Otani I, Fujii Y, Akari H, Mukai R, Mori K, Ono F, Kojima E, Machida M, Murakami K, Doi K, and Yoshikawa Y: Effects of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) in surface lymph nodes of rhesus monkeys chronically infected with simian immunodeficiency virus (SIVmac239). Journal of Veterinary Medical Science 59, 891-896, 1997.

16. Furuta RA, Shimano R, Ogasawara T, Inubushi R, Amano K, Akari H, Hatanaka M, Kawamura M and Adachi A: HIV-1 capsid mutants inhibit the replication of wild-type virus at both early and late infection phases. FEBS Letters 415, 231-234, 1997.

15. Kawamura M, Shimano R, Inubushi R, Amano K, Ogasawara T, Akari H and Adachi A: Cleavage of gag precursor is required for early replication phase of HIV-1. FEBS Letters 415, 227-230, 1997.

14. Akari H, Suzuki S, Ikeda K, Hoshino H, Tomono T, Murotsuka T, Terao K, Ito H, Yoshikawa Y: Prophylaxis of experimental HTLV-I infection in cynomolgus monkeys by passive immunization. Vaccine 15, 1391-1395, 1997.

13. Kannagi M, Nakamura T, Akari H, Kuroda MJ, Masuda T, Oka S, Iwamoto A, Kurata T, Higashi O and Harada S: Dual phasic suppression of viral replication following de novo human immunodeficiency virus type 1 (HIV-1) infection in lymphocytes of asymptomatic HIV-1 carriers. Leukemia 3, 545-547, 1997.

12. Akari H, Terao K, Murayama Y, Nam KH, Yoshikawa Y: Peripheral blood CD4+CD8+ double-positive lymphocytes in cynomolgus monkeys are of resting memory T lineage. International Immunology 9, 591-597, 1997.

11. Fujii Y, Mukai R, Murayama Y, Akari H, Machida M, Mori K, Takasaka M, Murakami K, Yoshikawa Y: Efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) on an ARC/AIDS rhesus macaque (Macaca mulatta) infected with simian immunodeficiency virus. Experimental Animals 46, 83-87, 1997.

10. Akari H, Mori K, Terao K, Otani I, Fukasawa M, Mukai R, Yoshikawa Y: In vitro immortalization of Old World monkey T lymphocytes with Herpesvirus Saimiri susceptible to productive infection of Simian Immunodeficiency Viruses. Virology 218, 382-388, 1996.

9. Akari H, Goto Y, Shinjo T: Detection of the cellular membrane proteins on human T cell leukemia virus type I. Archives of Virology 140, 375-382, 1995.

8. Akari H, Kuroda MJ, Shinjo T, El-Farrash MA, Harada S: Exposure of p19 matrix protein of human T cell leukemia virus type I (HTLV-I) on the surface of MOLT-4#8 cells after virus adsorption. Archives of Virology 136, 389-395, 1994.

7. Aidoo M, Nishiwaki O, Akari H, Brandful JA, Ampofo W, Hayami M, Ayisi NK: Differential reactivities of antibodies to HIV and HTLV-I in sera of suspected AIDS and ARC patients. West African Journal of Medicine 13, 150-151, 1994.

6. Akari H, Kannagi M, Shinjo T, Harada S: Simple assay system for detecting human T cell leukemia virus type I-binding cells and its application in titrating binding inhibitory antibodies. Laboratory Investigation 69, 629-634, 1993.

5. Tomonaga K, Katahira J, Fukasawa M, Hassan MA, Kawamura M, Akari H, Miura T, Goto T, Nakai M, Suleman M, Isahakia M, Hayami M: Isolation and characterization of simian immunodeficiency virus from African white-crowned mongabey monkeys(Cercocebus torquatus lunulatus). Archives of Virology 129, 77-92, 1993.

4. Kawamura M, Katahira J, Fukasawa M, Sakuragi JI, Ishikawa KI, Nakai M, Mingle JAA, Osei-Kwasi M, Akari H, Hishida O, Tomonaga K, Miura M, Hayami M: Isolation and characterization of a highly divergent HIV-2 [GH-2]: Generation of an infectious molecular clone and functional analysis of its rev-responsive element in response to primate retrovirus transactivators (Rev and Rex). Virology 188, 850-853, 1992.

3. Akari H, Sakuragi J, Takebe Y, Tomonaga K, Kawamura M, Fukasawa M, Miura T, Shinjo T, Hayami M: Biological characterization of human immunodeficiency virus type 1 and type 2 mutants in human peripheral blood mononuclear cells. Archives of Virology 123, 157-167, 1992.

2. Sakuragi JI, Fukasawa M, Shibata R, Sakai H, Kawamura M, Akari H, Kiyomasu T, Ishimoto A, Hayami M, Adachi A: Functional Analysis of long terminal repeats derived from four strains of simian immunodeficiency virus SIVagm in relation to other primate lentiviruses. Virology 185, 455-459, 1991.

1. Miura T, Sakuragi JI, Kawamura M, Fukasawa M, Moriyama EN, Gojobori T, Ishikawa KI, Mingle JAA, Nettey VBA, Akari H, Enami M, Tsujimoto H, Hayami M: Establishment of a phylogenetic survey system for AIDS-related lentiviruses and demonstration of a new HIV-2 subgroup. AIDS 4, 1257-1261, 1990.